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Label-free optical mapping for large-area biomechanical dynamics of multicellular systems

https://doi.org/10.1016/j.bios.2025.117281

Lin, Yen-Ju; Tan, Xing_Haw Marvin; Wang, Yijie; Chung, Pei-Shan; Zhang, Xiang; Wu, Ting-Hsiang; Wu, Tung-Yu; Deb, Arjun; Chiou, Pei-Yu (June 2025, Biosensors and Bioelectronics)

Free, publicly-accessible full text available June 1, 2026
Large-scale acoustic single cell trapping and selective releasing

https://doi.org/10.1039/D4LC00736K

Zhang, Xiang; Smith, Jacob; Zhou, Amanda Chengyi; Duong, Jacqueline Thuy-Tram; Qi, Tong; Chen, Shilin; Lin, Yen-Ju; Gill, Alexi; Lo, Chih-Hui; Lin, Neil_Y C; et al (March 2025, Lab on a Chip)

We introduce an acoustic microfluidic platform that efficiently traps and selectively releases individual cells using spherical air cavities embedded in a polydimethylsiloxane (PDMS) substrate for large scale manipulation.
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Free, publicly-accessible full text available March 11, 2026
Rapid prototyping of functional acoustic devices using laser manufacturing

https://doi.org/10.1039/D2LC00725H

Zhang, Xiang; Son, Rosa; Lin, Yen-Ju; Gill, Alexi; Chen, Shilin; Qi, Tong; Choi, David; Wen, Jing; Lu, Yunfeng; Lin, Neil Y.; et al (November 2022, Lab on a Chip)

Acoustic patterning of micro-particles has many important biomedical applications. However, fabrication of such microdevices is costly and labor-intensive. Among conventional fabrication methods, photo-lithography provides high resolution but is expensive and time consuming, and not ideal for rapid prototyping and testing for academic applications. In this work, we demonstrate a highly efficient method for rapid prototyping of acoustic patterning devices using laser manufacturing. With this method we can fabricate a newly designed functional acoustic device in 4 hours. The acoustic devices fabricated using this method can achieve sub-wavelength, complex and non-periodic patterning of microparticles and biological objects with a spatial resolution of 60 μm across a large active manipulation area of 10 × 10 mm 2 .
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